The Oakes Lab is in the Department of Biomedical Engineering at the University of Delaware. The Oakes Lab is focused on immunoengineering (also known as immune engineering) and directed by Dr. Robert Oakes. Dr. Oakes, who goes by Smitty Oakes, and his team are focused on integrating immunology, biomaterials, nanotechnology, regenerative medicine, and computational genomics to transform therapeutic interventions for autoimmunity and cancer metastasis.

Immunoengineering

Transforming treatment efficacy, patient quality-of-life, and therapeutic accessibility.

The Oakes Research Laboratory leverages nanoscale biomolecular self-assembly and microfabrication to engineer immunotherapies and drug delivery systems that target innate immunity to regulate autoimmunity and cancer metastasis.

Astrocytes (GFAP immunolabel) in the central nervous system. Image from a study on brain-machine interface neuroinflammation.
Copyright © 2025 Robert "Smitty" Oakes, PhD
Microcapsules formulated from immune signals, immune polyelectrolyte multilayer capsules (iPEMs). From an immunoengineering study on designing therapeutics for autoimmune disease in multiple sclerosis.
Copyright © 2025 Robert "Smitty" Oakes, PhD
Myelinated (MBP, green) axons (NF200, red) in the central nervous system dentate gyrus. From a study on neuroinflammation and demyelination in models of multiple sclerosis.
Copyright © 2025 Robert "Smitty" Oakes, PhD
3D printed microneedle array with conical tines. From a study on cancer vaccine design and delivery to skin.
Copyright © 2025 Robert "Smitty" Oakes, PhD
Microglia with surface (IBA1, green), phagocytic compartment (CD68, red), and nucleus (DAPI, blue) labeled. From a study on microglia interactions with astrocyte extracellular matrix.
Copyright © 2025 Robert "Smitty" Oakes, PhD

Lab Mission Statement

The mission of the Oakes Research Laboratory is to pursue transformative research and training for career and personal growth. As outlined in our Research description, we work in immunoengineering with a focus on how innate immune cells integrate cues from biomolecules and biomaterial delivery systems during disease. Our work integrates nanotechnology, microfabrication, and biomaterial approaches with immunology, gene expression regulation, single-cell and spatial transcriptomics to develop immunotherapies, drug delivery systems, and diagnostics. This approach to precision engineering and medicine can improve both the efficacy and accessibility of treatments for autoimmunity and cancer. Our core Values include innovation and translation, experimental rigor and responsibility, integration of diverse perspectives and tools, inclusion and belonging, enabling opportunities at multiple career stages, and maintaining a team-oriented philosophy. We implement these values in the laboratory and beyond through outreach initiatives. Every day, we focus on how we can innovate healthcare solutions that improve folks’ quality of life or give them more time with loved ones. – The Team